HLA-DR antigens and mitogenic factors released by PWM-stimulated T lymphocytes share the framework determinant recognized by the monoclonal antibody Q5/13 |
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Authors: | Francesco Indiveri Carlo Russo Vito Quaranta Michele A. Pellegrino Soldano Ferrone |
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Affiliation: | Department of Molecular Immunology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, California 92037 U.S.A. |
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Abstract: | Human T lymphocytes release factors which enhance the mitogenic response of B lymphocytes to PWM. These mitogenic factors share with HLA-DR antigens the framework determinant recognized by the monoclonal antibody Q5/13 (MoAb Q5/13) since adsorption of T-cell medium with an excess of insolubilized MoAb Q5/13 significantly reduces the enhancing activity of the T-cell supernatant on the proliferative response of B cells to PWM. On the other hand, incubation of the T-cell supernatant with an excess of insolubilized anti-HLA-A,B MoAb Q1/28 did not effect the activity of the T-cell supernatant in the proliferative assay. |
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