Experimental allergic encephalomyelitis: clinical disease and enhanced cellular transfer in the absence of lymphocyte proliferative responses against syngeneic MBP |
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| Authors: | S Hunter |
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| Institution: | 1. Institute of Medical and Clinical Biochemistry, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia;2. Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia;3. Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia;4. Institute of Rheumatology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia;1. Department of Immunology, IBISS, University of Belgrade, Belgrade, Serbia;2. Section of Organic Chemistry & Biochemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece;3. Institute of Materials Science and Computing, University Research Center of Ioannina (URCI), 45110, Ioannina, Greece |
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| Abstract: | Experimental allergic encephalomyelitis (EAE) was induced in Lewis rats using several different immunization protocols, and draining lymph node cells from these animals were assayed for proliferation against heterologous, homologous, and syngeneic MBP, and syngeneic spinal cord. Proliferative responses were largely stimulated by nonsyngeneic antigenic determinants and correlated better with the antigen used to induce EAE than with signs of autoimmune disease. Lymph node cells from rats immunized with either guinea pig spinal cord or syngeneic MBP did not proliferate measurably when restimulated in vitro with syngeneic MBP, yet lymphoid cells from these animals were enhanced in their capacity to transfer EAE following in vitro stimulation with syngeneic MBP. |
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