Active Metabolites in the Chronic Hepatotoxicity of Pyrrolizidine Alkaloids,including Otonecine Esters |
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| Authors: | C. C. J. CULVENOR J. A. EDGAR L. W. SMITH M. V. JAGO J. E. PETERSON |
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| Affiliation: | 1.CSIRO Division of Applied Chemistry,Melbourne;2.CSIRO Division of Animal Health,Melbourne |
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| Abstract: | WHEN she reported the chronic hepatotoxicity of the alkaloids senkirkine and hydroxysenkirkine, which are esters of the aminoalcohol otonecine, Schoental1 suggested that 1,2-epoxides rather than pyrrolic derivatives2,3 are the active metabolites of hepatotoxic pyrrolizidine alkaloids. We have results which confirm the hepatotoxicity of otonecine esters but argue against the suggested involvement of 1,2-epoxides. |
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