Adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate: concentrations in Morris hepatomas of different growth rates |
| |
| Authors: | Elizabeth W. Thomas Ferid Murad William B. Looney Harold P. Morris |
| |
| Affiliation: | 1. Division of Clinical Pharmacology, Departments of Pharmacology and Internal Medicine, University of Virginia School of Medicine, Charlottesville, Va. 22903, USA;2. Division of Radiobiology and Biophysics, Departments of Pediatrics and Radiology, University of Virginia School of Medicine, Charlottesville, Va. 22903, USA;3. Department of Biochemistry, Howard University School of Medicine, Washington D.C., 20001 U.S.A. |
| |
| Abstract: | Cyclic AMP and cyclic GMP levels were examined in Morris hepatoma explants in vivo. All eight tumor lines examined had significantly elevated cyclic AMP and cyclic GMP levels when compared to normal liver from tumor-bearing rats. No apparent correlation was observed between the rates of tumor growth and cyclic nucleotide levels; however, two tumor lines (3924A and 7288ctc) had very high levels of cyclic GMP. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
