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Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation |
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| Authors: | Weizhe Zhong Zhuqing Rao Jian Xu Yu Sun Haoran Hu Ping Wang Yongxiang Xia Xiongxiong Pan Weiwei Tang Ziyi Chen Haoming Zhou Xuehao Wang |
| Affiliation: | 1. Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing China ; 2. Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Nanjing China ; 3. NHC Key Laboratory of Living Donor Liver Transplantation, Nanjing Medical University, Nanjing China ; 4. Department of Anesthesiology, The First Affiliated Hospital with Nanjing Medical University, Nanjing China |
| Abstract: | |
| Keywords: | aging macrophage mitochondrial DNA mitophagy sterile inflammation stimulator of interferon genes |