VE-cadherin at a glance |
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Authors: | Luca Bravi Elisabetta Dejana Maria Grazia Lampugnani |
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Institution: | 1. FIRC Institute of Molecular Oncology (IFOM) Fondazione, Via Adamello 16, 20139, Milan, Italy 2. Department of Biosciences, School of Sciences, Milan University, Milan, Italy 3. Mario Negri Institute for Pharmacological Research, Milan, Italy
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Abstract: | Although being a monolayer the vascular endothelium controls fundamental vessel functions such as permeability, leukocyte extravasation and angiogenesis. The endothelial selective transmembrane constituent of adherens junctions, Vascular Endothelial- (VE-) cadherin plays a crucial role in the regulation of such activities. The signaling pathways controlled by VE-cadherin as well as the ones that regulate VE-cadherin activity start to be elucidated. This delineates a complex network of molecular and functional interactions that can be altered in pathologies. |
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