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Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
Authors:Hamano Emi  Hijikata Minako  Itoyama Satoru  Quy Tran  Phi Nguyen Chi  Long Hoang Thuy  Ha Le Dang  Ban Vo Van  Matsushita Ikumi  Yanai Hideki  Kirikae Fumiko  Kirikae Teruo  Kuratsuji Tadatoshi  Sasazuki Takehiko  Keicho Naoto
Affiliation:Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Japan.
Abstract:We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2',5'-oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p=0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position -88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p=0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level.
Keywords:Severe acute respiratory syndrome   SARS associated coronavirus   Association study   Polymorphism   Oligoadenylate synthetase 1   Myxovirus resistance-A   Interferon   Vietnam
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