| 大鼠鞘内注射多巴胺受体激动剂与拮抗剂对痛及针刺镇痛的影响 |
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| 作者姓名： | Gao X Xin BM Zhu CB Wu GC Xu SF |
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| 作者单位： | 上海医科大学医学神经生物学国家重点实验室,上海,200032 |
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| 基金项目： | 国家自然科学基金,上海市科委资助项目,39230360,95×D14004及97QB1408,, |
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| 摘 要： | 在大鼠电刺激甩测痛模型上,应用鞘内注射（ｉｔ）多巴胺（ＤＡ）受体选择性激动剂与拮抗剂,分析大鼠脊髓ＤＡ受体亚型Ｄ１和Ｄ２在痛及针刺镇痛（ＡＡ）中的作用。结果显示,在正常清醒大鼠,ｉｔ Ｄ２受体选择性激动剂,Ｙ１７１５５５（ＬＹ）或Ｄ１／Ｄ２受体激动剂阿朴吗啡（ＡＰＯ）有镇痛作用（呈剂量依赖式增加）,并加强ＡＡ,而ｉｔ Ｄ１受体选择性激动剂ＳＫＦ３８３９３（ＳＫＦ）对痛及ＡＡ均无影响;ｉｔ Ｄ１受体
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| 关 键 词： | 多巴胺 胺体 镇痛 鞘内注射 针刺疗法 |
| 修稿时间： | 1996年12月3日 |
Effect of intrathecal injection of dopamine receptor agonists/antagonists on pain and acupuncture analgesia in rats |
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| Gao X,Xin BM,Zhu CB,Wu GC,Xu SF.Effect of intrathecal injection of dopamine receptor agonists/antagonists on pain and acupuncture analgesia in rats[J].Acta Physiologica Sinica,1998,50(1):43-48. |
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| Authors: | Gao X Xin B M Zhu C B Wu G C Xu S F |
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| Institution: | State Key Laboratory of Medical Neurobiology, Shanghai Medical University, Shanghai 200032. |
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| Abstract: | Some selective dopamine receptor agonists and antagonists were tested on rat tail flick model to investigate the role of D1 and D2 dopamine receptor in pain and acupuncture analgesia (AA). It was found that intrathecal administration (i.t.) of D2 receptor agonist LY171555 or D1/D2 receptor agonist apomorphine increased pain threshold and had a potentiating effect on AA. In contrast, D1 receptor agonist SKF38393 had no effect. It D1 receptor antagonist SCH23390 or D2 receptor antagonist sulpiride attenuated the effect of AA. The results suggest that D2 receptor is involved in pain modulation and activation of D2 receptor and enhances AA in the spinal cord, while such effect is absent in D1 receptor and inactivation of D1 receptor attenuates AA. |
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| Keywords: | dopamine receptor acupuncture analgesia intrathecal administration apomorphine SKF38393 LY171555 sulpiride SCH23390 |
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