Conformational studies of a benzodiazepine-like peptide in SDS micelles by circular dichroism, 1H NMR and molecular dynamics simulation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

Conformational studies of a benzodiazepine-like peptide in SDS micelles by circular dichroism, 1H NMR and molecular dynamics simulation

Authors:	Marc Lecouvey Céline Frochot Laurent Miclo Piotr Orlewski Michel Marraud Jean-Luc Gaillard Manh Thong Cung Régis Vanderesse

Institution:	(1) LCPM, CNRS-URA 494, ENSIC-INPL, BP 451, F-54001 Nancy Cedex, France;(2) LBSA, Unité associé à l'INRA, Université Henri Poincaré, BP 239, F-54506 Vandœuvre lès Nancy Cedex, France

Abstract:	Summary The conformation of a benzodiazepine-like decapeptide corresponding to the YLGYLEQLLR fragment of a casein has been examined in a sodium dodecyl sulfate micellar medium using circular dichroism, two-dimensional¹H NMR spectroscopy and restrained molecular dynamics simulation. The decapeptide adopts an amphipathic 3₁₀-helicoid structure in which the E⁶...R¹⁰ ionic bridge stabilizes the C-terminus.

Keywords:	Benzodiazepines Circular dichroism GABA_A receptor Micellar medium Molecular dynamics 2D NMR
本文献已被 SpringerLink 等数据库收录！