Structure of the DNA binding domain of E. coli SSB bound to ssDNA |
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| Authors: | Raghunathan S Kozlov A G Lohman T M Waksman G |
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| Institution: | Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Campus Box 8231, 660 S. Euclid Ave., Saint Louis, Missouri 63110, USA. |
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| Abstract: | The structure of the homotetrameric DNA binding domain of the single stranded DNA binding protein from Escherichia coli (Eco SSB) bound to two 35-mer single stranded DNAs was determined to a resolution of 2.8 A. This structure describes the vast network of interactions that results in the extensive wrapping of single stranded DNA around the SSB tetramer and suggests a structural basis for its various binding modes. |
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