Activation of protein kinase C by non-phorbol tumor promoter, mezerein |
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Authors: | R Miyake Y Tanaka T Tsuda K Kaibuchi U Kikkawa Y Nishizuka |
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Affiliation: | 1. Department of Biochemistry, Kobe University School of Medicine, Kobe 650, Japan;2. Department of Cell Biology, National Institute for Basic Biology, Okazaki 444, Japan |
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Abstract: | Mezerein, classified as a second-stage tumor promoter, has no diacylglycerol-like structure in its molecule, but can activate protein kinase C both in vitro and in vivo. This non-phorbol diterpene competitively inhibits the specific binding of a radioactive tumor-promoting phorbol ester to the enzyme. It is suggestive that tumor-promoting phorbol esters and mezerein cause analogous changes in the membrane to activate protein kinase C, and utilize this protein kinase as a common receptive protein for tumor promotion. |
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