Pattern triplications following genetic ablation on the wing ofDrosophila |
| |
Authors: | Pedro Santamaria Janet Deatrick Neel B. Randsholt |
| |
Affiliation: | (1) Centre de Génétique Moléculaire du C.N.R.S., F-91198 Gif-sur-Yvette Cedex, France;(2) Laboratoire propre du C.N.R.S., associe à l'Université Pierre et Marie Curie, Paris VI, France |
| |
Abstract: | Summary The effects ofpolyhomeotic (ph) mutants in imaginal cells have been studied in a clonal analysis. Clones of cells, homozygous forph, sort-out after a few divisions, probably as a consequence of modified cell affinities. The dorso-ventral margin of the wing has special characteristics that retard this phenomenon. The formation and exclusion of a clone of 8–16 cells affect the polarity of the wild-type neighbour cells and can provoke pattern triplications. The results suggest that a defect in intercellular communication prevents the wild-type cells from maintaining coordinated positional information. The cells react by regenerative growth, and reorganize into a new pattern. The pleiotropic phenotypes ofph mutants are explained according to a common hypothesis aboutph + function. |
| |
Keywords: | Cell communication Pattern formation Cell differentiation trans-regulatory genes Drosophila |
本文献已被 SpringerLink 等数据库收录! |