GlaxoSmithKline, Research Department, Parque Tecnológico de Madrid, Severo Ochoa, 2. 28760 Tres Cantos, Madrid, Spain.
Abstract:
A number of novel 3'-O-acyl and alkyl sordarins were synthesised for structure-activity relationship studies. Many of these derivatives exhibit high activity against Candida albicans, Candida pseudotropicalis, Candida tropicalis and Cryptococcus neoformans.