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An unusual case of a basophilic variant of chronic myelogenous leukemia |
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| Authors: | D Bondare D Grasmane I Baravika V Petuchov L Grinberga I Medne M Krischtsuna M Sihle |
| Abstract: | The described basophilic variant of CML in blastic crisis was characterized by a distinct hyperhistaminemia, a moderate hypocoagulation and an insufficiently effective cytostatic therapy. Cell kinetic was characterized by a marked diminution of the whole marketing index (with H3-thymidine) of blasts and immature basophils with simultaneous prolongation of the generation time in comparison to myeloblasts at the chronic stage of the CML. Aneuploid cell clones prevailed in the bone-marrow. |
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