CYP3 a likely candidate for the structural gene of ISO-2 cytochrome C in Saccaromyces cerevisiae. |
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Authors: | Jacqueline Verdière Eric Petrochilo |
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Affiliation: | Centre de Génétique Moléculaire du C.N.R.S., 91190 Gif-sur-Yvette, France |
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Abstract: | Mutations specific for iso-2 cytochrome c were obtained in strains bearing a deletion of the structural gene of iso-1-cytochrome c. In this genetic context the mutations entail an inability to grow on glycerol. One of these mutants was shown to have a modified iso-2-cytochrome c as witnessed by its lack of stability and modified chromatographic behaviour. Genetic studies showed the mutations to be allelic to the mutation cyp3-15 previously identified by Clavilier (1) as a specific enhancer of iso-2-cytochrome c synthesis. The simplesthypothesis to explain the results is that the CYP3 locus is the structural gene for iso-2-cytochrome c. |
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