Synthesis of oligosaccharide fragments of the repeating unit of Salmonella kentucky O-specific polysaccharide and conversion of the oligosaccharides into the glycosyl phosphates |
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| Authors: | V I Torgov C A Panossian V N Shibaev |
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| Institution: | 1. AIMM Therapeutics, Academic Medical Center, Amsterdam, The Netherlands;2. Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands;1. Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91711, United States of America;2. Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, United States of America;3. Department of Neurobiology, University of Chicago, Chicago, IL 60637, United States of America |
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| Abstract: | alpha-D-Man-(1----2)-alpha-D-Man-(1----3)-D-Gal, a structural fragment of the main chain of Salmonella serogroups C2 and C3 O-specific polysaccharides, and the isomer with the central residue beta have been synthesised, as have some oligosaccharides related to the structure of the O-specific polysaccharide of S. kentucky (serogroup C3), namely, alpha-D-Glc-(1----4)-D-Gal, alpha-D-Man-(1----3)-alpha-D-Glc-(1----4)]-D-Gal, and alpha-D-Man-(1----2)-alpha-D-Man-(1----3)-alpha-D-Glc-(1----4)]-D-Gal, and the isomers with the D-Glc unit beta. Each oligosaccharide was converted into the alpha-glycosyl phosphate. |
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