Connective Tissue Growth Factor (CTGF/CCN2) enhances lactogenic differentiation of mammary epithelial cells via integrin-mediated cell adhesion |
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| Authors: | Bethanie L Morrison Cynthia C Jose Mary Lou Cutler |
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| Affiliation: | (1) Department of Pathology, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA;(2) Drug Mechanism Group - Developmental Therapeutics Program, SAIC Frederick/NCI-FCRDC, Bldg. 320, Rm 8, Frederick, MD 21702, USA |
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| Abstract: | Background Connective Tissue Growth Factor (CTGF/CCN2), a known matrix-associated protein, is required for the lactogenic differentiation of mouse mammary epithelial cells. An HC11 mammary epithelial cell line expressing CTGF/CCN2 was constructed to dissect the cellular responses to CTGF/CCN2 that contribute to this differentiation program. |
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