Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice |
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| Authors: | Timothy M Griffin Beverley Fermor Janet L Huebner Virginia B Kraus Ramona M Rodriguiz William C Wetsel Li Cao Lori A Setton Farshid Guilak |
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| Institution: | (1) Department of Surgery, Duke University Medical Center, 375 Medical Sciences Research Building, Durham, NC 27710, USA;(2) Department of Medicine, Duke University Medical Center, 2100 Erwin Road, Durham, NC 27710, USA;(3) Department of Psychiatry and Behavioral Sciences, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, 2100 Erwin Road Durham, NC 27710, USA;(4) Departments of Neurobiology and Cell Biology, Duke University Medical Center, 2100 Erwin Road, Durham, NC 27710, USA;(5) Department of Biomedical Engineering, Duke University, 2136 Hudson Hall, Durham, NC 27708, USA;(6) Program in Free Radical Biology and Aging, Oklahoma Medical Research Foundation, Biochemistry and Molecular Biology, University of Oklahoma Health Science Center, 825 NE 13th St, Oklahoma City, OK 73104, USA |
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| Abstract: | Introduction Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints.
The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well understood,
but may include systemic inflammation associated with increased adiposity. In this study, we examined biomechanical, neurobehavioral,
inflammatory, and osteoarthritic changes in C57BL/6J mice fed a high-fat diet. |
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