| RNA interference: a promising approach to antiviral therapy? |
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| 作者姓名： | Silva JM Hammond SM Hannon GJ |
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| 摘 要： |
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RNA interference: a promising approach to antiviral therapy? |
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| Silva JM,Hammond SM,Hannon GJ.RNA interference: a promising approach to antiviral therapy?[J].Trends in Molecular Medicine,2002,8(11):505-508. |
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| Authors: | Silva Jose M Hammond Scott M Hannon Gregory J |
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| Institution: | 1. Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan;2. Department of Dental Regenerative Medicine, Center of Advanced Medicine for Dental and Oral Diseases, National Center for Geriatrics and Gerontology, Obu, Japan;3. Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Suita, Japan;1. Department of Genome Science and Technology, University of Tennessee, Knoxville, TN, USA;2. Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996-0845, USA;1. Medical Affairs, Sanofi Pasteur Korea, Seoul, Republic of Korea;2. Health Economics and Outcome Research, Sanofi Pasteur Asia & JPAC Region, Singapore |
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| Abstract: | RNA interference (RNAi) has developed into a powerful tool for probing gene function. Recently, several reports have demonstrated the use of RNAi for attenuation of viral infection and replication in cultured cells. Furthermore, RNAi has been shown to suppress gene expression in adult animals. Although these results suggest that RNAi might become a novel therapeutic approach, significant hurdles must still be overcome before RNAi can be exploited in the fight against human disease. |
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