| 膜片钳技术在动脉粥样硬化研究中的应用 |
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| 引用本文： | 唐朝克,杨永宗. 膜片钳技术在动脉粥样硬化研究中的应用[J]. 生命科学研究, 2002, 0(Z1) |
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| 作者姓名： | 唐朝克 杨永宗 |
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| 作者单位： | 南华大学心血病研究所，南华大学心血病研究所 中国湖南 衡阳 421001，中国湖南 衡阳 421001 |
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| 摘 要： | 膜片钳技术是一种先进的电生理技术,在生命科学研究中已得到了广泛的应用.最近几年已把它运用于研究动脉粥样硬化血管平滑肌细胞离子通道电生理特性的改变.研究发现血管平滑肌细胞的凋亡与K+通道活动增加有关,在动脉粥样硬化发生与发展过程中大电导型钙激活钾通道起着重要的功能作用.某些药物影响动脉粥样硬化血管平滑肌细胞离子通道而发挥作用.膜片钳技术给动脉粥样硬化发病机理研究带来了新的亮点.
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| 关 键 词： | 膜片钳技术 动脉粥样硬化 血管平滑肌细胞 离子通道 |
Patch Clamp Technique and its Application to Studyingof Atherosclerosis |
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| TANG Chao-ke,YANG Yong-zong. Patch Clamp Technique and its Application to Studyingof Atherosclerosis[J]. Life Science Research, 2002, 0(Z1) |
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| Authors: | TANG Chao-ke YANG Yong-zong |
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| Abstract: | The patch clamp recording techniques is an advanced electrophysiological technique, which has been widely used for research in the life science research field. It vas applied to studying on the electrophysiological character of ion channels in atherosclerotic vascular smooth muscle cells. It has been found that apoptosis of vascular smooth muscle cells vas relate with increase of K+ channel action. Large-conductance BKCa, channel plays a important role in development of atherosclerosis. Some drugs may affect ion channels in atherosclerotic vascular smooth muscle cells. The patch clamp technique bring about new light set in studying on mechanism of atherosclerotic development. |
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| Keywords: | patch clamp techniques atherosclerosis vascular smooth muscle cells ion channels |
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