Chromosomal instability in Afrotheria: fragile sites,evolutionary breakpoints and phylogenetic inference from genome sequence assemblies |
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| Authors: | Aurora Ruiz-Herrera Terence J Robinson |
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| Institution: | (1) Evolutionary Genomics Group, Department of Botany & Zoology, University of Stellenbosch, Private Bag X1, Matieland, 7602, South Africa;(2) Dipartimento di Genetica e Microbiologia, Universita' degli Studi di Pavia, Via Ferrata 1, Pavia, 27100, Italy;(3) Evolutionary Genomics Group, Department of Botany & Zoology, University of Stellenbosch, Private Bag X1, Matieland, 7602, South Africa |
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| Abstract: | Background Extant placental mammals are divided into four major clades (Laurasiatheria, Supraprimates, Xenarthra and Afrotheria). Given
that Afrotheria is generally thought to root the eutherian tree in phylogenetic analysis of large nuclear gene data sets,
the study of the organization of the genomes of afrotherian species provides new insights into the dynamics of mammalian chromosomal
evolution. Here we test if there are chromosomal bands with a high tendency to break and reorganize in Afrotheria, and by
analyzing the expression of aphidicolin-induced common fragile sites in three afrotherian species, whether these are coincidental
with recognized evolutionary breakpoints. |
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