Identifying peptide ligands for cell surface receptors using cell-growth-on-bead assay and one-bead one-compound combinatorial library |
| |
| Authors: | Derick H. Lau Linlang Guo Ruiwu Liu Aimin Song Chunkui Shao Kit S. Lam |
| |
| Affiliation: | (1) Department of Internal Medicine and Veteran Administration Northern California Health System, Division of Hematology and Oncology, University of California Davis Cancer Center, Sacramento, CA 95817, USA |
| |
| Abstract: | A cell-growth-on-bead assay was used to screen one-bead, one-compound combinatorial libraries for peptide ligands that attract attachment and growth of human lung cancer cells. A consensus cyclic peptide sequence, d-cys-l-asn-l-gly-l-arg-l-gly-l-glu-l-gln-d-cys (cNGRGEQc), was identified as a ligand for a cell surface receptor,  3 1 integrin. This peptide ligand and its analogs have the potential to be used as diagnostic and therapeutic agents for lung cancer. |
| |
| Keywords: | cell-growth-on-bead assay integrin lung cancer one-bead one-compound combinatorial library peptide ligand |
| 本文献已被 SpringerLink 等数据库收录！ |
