Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest |
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| Authors: | Christopher J Armit Shirley O'Dea Alan R Clarke David J Harrison |
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| Affiliation: | (1) CRC Laboratories, Department of Pathology, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK;(2) Mucosal Immunology Laboratory, Biology Department, , N.U.I. Maynooth, Co.Kildare, Ireland;(3) Cardiff University School of Biosciences, Cardiff, CF10 3US, UK |
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| Abstract: | Background The p53 oncosuppressor protein is a critical mediator of the response to injury in mammalian cells and is mutationally inactivated in the majority of lung malignancies. In this analysis, the effects of p53-deficiency were investigated in short-term primary cultures of murine bronchiolar Clara cells. Clara cells, isolated from gene-targeted p53-deficient mice, were compared to cells derived from wild type littermates. |
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