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Chromosome lesions in amniotic fluid cell cultures
Authors:G. Simoni  L. Larizza  N. Sacchi  G. Della Valle  F. Dambrosio  L. De Carli
Affiliation:(1) Istituto di Biologia Generale, Facoltà di Medicina, Università degli Studi di Milano, Via Viotti, 5, 20122 Milan, Italy;(2) Clinica Ostetrica e Ginecologia I, Facoltà di Medicina, Università degli Studi di Milano, 20133 Milan, Italy;(3) Present address: Istituto di Genetica, Università degli Studi di Pavia, Italy
Abstract:Summary The frequencies of chromosome lesions were determined on 3537 mitoses in samples of varying sizes from cultures of 25 amniotic fluid specimens taken from patients at cytogenetic risk. The average percentage values of aberrant cells, including and excluding gaps, were 12.5 and 4.9, respectively. The corresponding values for fibroblasts and peripheral blood lymphocytes from normal adult donors, calculated under the same laboratory conditions, were 5.0 (including gaps) and 2.4 (excluding gaps) and 2.4 (including gaps) and 1.0 (excluding gaps), respectively. The hypothesis of a correlation between the increased incidence of chromosome lesions and the occurrence of abnormal karyotypes in amniotic fluid cell cultures is discussed.
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