An autoradiographic study of satellite cell differentiation into regenerating myotubes following transplantation of muscles in young rats |
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| Authors: | Mikel H. Snow Ph.D. |
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| Affiliation: | (1) Department of Anatomy, University of Southern California, School of Medicine, Los Angeles, California, USA |
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| Abstract: | Summary Satellite cells were traced autoradiographically during the regeneration of skeletal muscle in young Sprague-Dawley rats. Approximately 31% of the satellite cells in uninjured muscles appeared labelled after three injections of tritiated thymidine; none of the myonuclei were labelled in the same muscles. Four to six days after transplanting the radioactive muscles to non-radioactive littermates, regenerating myotube nuclei in the host appeared labelled. Thus, this study confirms that satellite cells in young rats can differentiate into multinucleated myotubes following muscle injury.Supported by NIH grant No. 5 S01-RR05356-13I wish to acknowledge the excellent technical assistance of Ms. Amy Erisman |
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| Keywords: | Skeletal muscle Satellite cells Regeneration Electron microscopy Autoradiography |
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