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Increased tritiated thymidine-labeling index of bone marrow myeloblasts following BCG administration in man |
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| Authors: | M Rozencweig P Stryckmans J P Fichefet Mireille Socquet |
| Institution: | (1) Service de Médecine et Laboratoire d'Investigation Clinique, Institut Jules Bordet, B-1000 Brussels, Belgium;(2) Presently at the Cancer Therapy Evaluation Program, National Cancer Institute, 20014 Bethesda, Maryland, USA;(3) Service de Médecine, Centre de Gériatrie, Traumatologie, et Réadaptation, B-6418 Montignies le Tilleul, Belgium;(4) National Institutes of Health, National Cancer Institute, Building 37, Room 6 A17, 20014 Bethesda, Maryland, USA |
| Abstract: | Summary The in vitro (3H)thymidine-labeling index of bone marrow myeloblasts was determined in eight hematologically normal individuals before and after the administration of Bacillus Calmette-Guérin twice weekly for 2 weeks. The mean labeling indexes of myeloblasts were 30.5 and 45.2% respectively (P<0.004).Further characterization of this stimulation of proliferation of bone marrow myeloblasts could provide some rationale for combining cytotoxic drugs and immunotherapy in cancer patients.The present work was supported by the Fonds Cancérologique de la Caisse Générale d'Epargne et de Retraite de Belgique and by Euratom Grant No. 161-76-1. B 10B and by the NCI Grant No. 2R 10CA 11488-07 |
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