In the era of systematic reviews, does the size of an individual trial still matter |
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| Authors: | Guyatt Gordon H Mills Edward J Elbourne Diana |
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| Institution: | Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. guyatt@mcmaster.ca |
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| Abstract: | BACKGROUND TO THE DEBATE: Systematic reviews that combine high-quality evidence from several trials are now widely considered to be at the top of the hierarchy of clinical evidence. Given the primacy of systematic reviews-and the fact that individual clinical trials rarely provide definitive answers to a clinical research question-some commentators question whether the sample size calculation for an individual trial still matters. Others point out that small trials can still be potentially misleading. |
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