Plasmodium cynomolgi: folic acid antagonist combinations for treatment of malaria in rhesus monkeys |
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| Authors: | K E Kinnamon D E Davidson |
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| Affiliation: | Division of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington, D.C., 20012, U.S.A.;Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand |
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| Abstract: | The dihydrofolate reductase inhibitor 2,4-diamino-6-(2-naphthyl-sulfonyl)-quinazoline and its tetrahydro analog 2,4-diamino-6-(2-naphthyl-sulfonyl)-5,6,7,8-tetrahydroquinazoline were evaluated for possible synergism in treating trophozoite-induced Plasmodium cynomolgi var. bastianellii malaria of rhesus monkeys. The degree of synergism, if it exists, was found to be not nearly as great as observed previously with this combination of drugs against Plasmodium berghei infections of mice. |
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| Keywords: | Malaria Protozoa, parasitic Antifols Chemotherapy Dihydrofolate reductase inhibitors Synergism, drugs Rhesus monkey Inhibitors, metabolic DHF, dihydrofolate THF, tetrahydrofolate |
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