Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: functional impairment of Golgi apparatus in the early phases of such injury |
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| Authors: | G Poli E Chiarpotto E Albano D Cottalasso G Nanni U M Marinari A M Bassi M U Dianzani |
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| Affiliation: | 1. Institute of General Pathology, Corso Raffaello 30, 10125, Torino, Italy;2. Institute of General Pathology, Via L.B. Alberti 2, 16132, Genova, Italy |
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| Abstract: | Functional change of liver Golgi apparatus during carbon tetrachloride (CCl4) poisoning was demonstrated both in rat isolated hepatocytes and in the whole animal. The "in vitro" experimental model provided evidence of Golgi derangement early after giving the haloalkane. The "in vivo" analyses also showed that such an alteration involves both formative and secretory sides of the subcellular structure. |
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