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Human-macaque comparisons illuminate variation in neutral substitution rates
Authors:Svitlana Tyekucheva  Kateryna D Makova  John E Karro  Ross C Hardison  Webb Miller  Francesca Chiaromonte
Affiliation:(1) Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, PA 16802, USA;(2) Department of Statistics, The Pennsylvania State University, University Park, PA 16802, USA;(3) Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA;(4) Department of Computer Science and System Analysis, Miami University, Oxford, OH 45056, USA;(5) Department of Microbiology, Miami University, Oxford, OH 45056, USA;(6) Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA;(7) Department of Computer Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USA
Abstract:

Background  

The evolutionary distance between human and macaque is particularly attractive for investigating local variation in neutral substitution rates, because substitutions can be inferred more reliably than in comparisons with rodents and are less influenced by the effects of current and ancient diversity than in comparisons with closer primates. Here we investigate the human-macaque neutral substitution rate as a function of a number of genomic parameters.
Keywords:
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