| 肿瘤干细胞及其耐药机制 |
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| 作者姓名： | Ou Y Guo XL |
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| 作者单位： | 山东大学药学院新药药理研究所,济南,250012;山东大学药学院新药药理研究所,济南,250012 |
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| 摘 要： | 肿瘤干细胞是存在于造血系统肿瘤和一些实体瘤中具有干细胞特性的细胞。肿瘤干细胞假说认为,经药物治疗后肿瘤复发和转移与肿瘤干细胞残存有密切关系。其原因可能是肿瘤干细胞高表达ABC转运蛋白和Bcl-2抗凋亡蛋白,同时其本身又具有一些干细胞特性。对肿瘤干细胞耐药机制的研究,将有助于发现新的肿瘤治疗靶点和更好的抗癌策略。
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| 关 键 词： | 肿瘤干细胞 耐药性 ABC转运蛋白 治疗 |
Tumor stem cells and drug resistance |
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| Ou Y,Guo XL.Tumor stem cells and drug resistance[J].Progress in Physiological Sciences,2007,38(2):115-119. |
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| Authors: | Ou Yang Guo Xiu-Li |
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| Institution: | Department of Newdrug Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China |
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| Abstract: | The tumor stem cells possessing stem cells properties have been described in haematopoietic cancer and some solid tumors. It is believed the regeneration and displace of cancer after chemotherapy have tighten relation with the residual tumor stem cells. The main reason is that tumor stem cells over-express ATP-binding cassette drug transporters and Bcl-2. Moreover, tumor stem cells have the character of stem cells. More insight into the mechanisms of tumor stem cells might help lead to new therapeutic targets and better anticancer strategies. |
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| Keywords: | tumor stem cells drug resistance ATP-binding cassette drug transporters therapy |
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