The effect of ranitidine on cellular immunity in patients with multiple myeloma |
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Authors: | Hans Jørgen Nielsen Henrik Nielsen Flemming Moesgaard Niels Tvede Kim Klarlund Bendt Mansa Aage Drivsholm |
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Affiliation: | (1) Department of Surgical Gastroenterology 235, Hvidovre University Hospital, DK-2650 Hvidovre, Denmark;(2) Department of Hematology, Hvidovre University Hospital, Denmark;(3) Dept. of Clin. Microbiology, Statens Seruminstitut, Rigshospitalet;(4) Laboratory of Medical Immunology, Rigshospitalet;(5) Blood Bank, Rigshospitalet;(6) Statens Seruminstitut, Laboratory for Immunochemistry, Copenhagen, Denmark |
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Abstract: | Summary Multiple myeloma is characterized by an increased susceptibility to infections and to other malignancies. In a double-blind, placebo-controlled study the potential impact of immunomodulation by ranitidine was studied in 20 patients with multiple myeloma. Three patients were untreated, while 17 after previous cytotoxic therapy were in a stable phase of their disease. All were without clinical signs of infections and at that time had not been treated with other immunomodulating agents. The patients were randomized to oral ranitidine 300 mg twice a day for 21 days or placebo, and several immunological parameters related to multiple myeloma were studied. The blood monocyte chemotactic response was improved in patients treated with ranitidine, and superoxide anion production increased from 2.02 nmol/min to 3.86 nmol/min (median values), while it was unchanged in patients given placebo (2.19–2.25 nmol/min) (P <0.005 between groups). Among ranitidine-treated patients spontaneous NK cell activity was unchanged, while in vitro interleukin-2- and interferon- -stimulated NK cell activity decreased (P <0.03, respectively). As production of oxygen radicals constitutes an important mechanism of monocyte killing activity against microorganisms and probably against malignant cells, it is suggested that ranitidine may be of beneficial impact in the treatment of multiple myeloma. |
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