|
|||||
|
|
Serum amyloid A-induced IL-6 production by rheumatoid synoviocytes |
|
| Authors: | Koga Tomohiro Torigoshi Takafumi Motokawa Satoru Miyashita Taichiro Maeda Yumi Nakamura Minoru Komori Atsumasa Aiba Yoshihiro Uemura Takashi Yatsuhashi Hiroshi Ishibashi Hiromi Eguchi Katsumi Migita Kiyoshi |
| Institution: | Clinical Research Center and Department of Rheumatology, NHO Nagasaki Medical Center, Omura, Japan. |
| Abstract: | In this study, we investigated the role of serum amyloid A protein (SAA) in the production of interleukin-6 (IL-6) using rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Recombinant SAA stimulation induced the production of pro-inflammatory cytokine, IL-6, from RA-FLS. The signaling events induced by SAA included the activation of the mitogen-activated protein kineases, p38 and JNK1/2 and the activation of nuclear factor-kappa B (NF-kappaB). Inhibitor studies have shown SAA-induced IL-6 production to be down-regulated by NF-kappaB inhibition and partially inhibited by p38 or JNK inhibitors. Our findings demonstrate that SAA is a significant inducer of IL-6, which is critically involved in RA pathogenesis. |
| Keywords: | FLS fibroblast-like synoviocytes FPRL1 N-formyl peptide receptor-like 1 IL-6 interleukin-6 MAPKs mitogen-activated protein kineases NF-κB nuclear factor-kappa B RA rheumatoid arthritis SAA serum amyloid A protein |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |