The ontogenetic development of the follicular dendritic cell |
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| Authors: | Dr Christine D Dijkstra E W A Kamperdijk E A Döpp |
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| Institution: | (1) Department of Histology, Free University, Amsterdam, The Netherlands;(2) Department of Electronmicroscopy, Medical Faculty, Free University, Amsterdam, The Netherlands;(3) Dept. of Histology, Medical Faculty, Free University, P.O. Box 7161, 1007 MC Amsterdam, The Netherlands |
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| Abstract: | Summary After intravenous injection of horseradish peroxidase (HRP)-anti-HRP complexes in 21-day-old rats, complex trapping occurs on reticulum cells, forming the stroma of primary follicles of spleens. After intravenous injection of the same complexes in young adult rats (48 days old), trapping occurs on characteristic follicular dendritic cells (FDCs) located in well-developed germinal centers. These results strongly suggest that the follicular dendritic cell originates from a reticulum cell.Abbreviations
FDC
follicular dendritic cell
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FRC
fibroblastic reticulum cells
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HRP
horseradish peroxidase
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RC
reticulum cell |
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| Keywords: | Follicular dendritic cell Ontogeny Immunecomplex trapping Spleen (rat) Reticulum cell |
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