Gene transfer into eukaryotic cells using activated polyamidoamine dendrimers |
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Authors: | Dennig Jörg Duncan Emma |
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Affiliation: | QIAGEN GmbH, Hilden, Germany. j.dennig@de.qiagen.com |
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Abstract: | The development of efficient methods to transfer genes into eukaryotic cells is important for molecular biotechnology. A number of different technologies to mediate gene transfer have been developed over the last 35 years, but most have drawbacks such as cytotoxicity, low efficiency and/or restricted applicability. Activated polyamidoamine (PAMAM)-dendrimers provide a new technology for gene transfer that offers significant advantages over classical methods. Reagents based on this technology provide high gene transfer efficiencies, minimal cytotoxicity, and can be used with a broad range of cell types. This technology could also be useful for in vivo gene transfer in gene therapy applications. |
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