The enantioselectivity of the cellular deoxynucleoside kinases. |
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| Authors: | J Wang J Chattopadhyaya S Eriksson |
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| Institution: | Department of Veterinary Medical Chemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden. |
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| Abstract: | Cytosolic thymidine kinase (TK1) and deoxycytidine kinase (dCK) and the mitochondrial thymidine kinase (TK2) and deoxyguanosine kinase (dGK) phosphorylate deoxynucleosides and their analogs. Recombinant human TK1 only phosphorylated beta-D Thd, but recombinant TK2, dCK and dGK all phosphorylated equally well beta-D and beta-L as well as to some extent alpha-D and alpha-L deoxynucleosides. |
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