Breaking the cell cycle of HSCs by p57 and friends |
| |
| Authors: | Tesio Melania Trumpp Andreas |
| |
| Institution: | Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. |
| |
| Abstract: | The cell cycle regulators involved in maintaining the quiescence, and thereby the self-renewal capacity, of somatic stem cells have long been elusive. Two new Cell Stem Cell articles in this issue (Matsumoto et?al., 2011; Zou et?al., 2011) now show that the CDK inhibitor p57 is a crucial brake for cycling HSCs, and links self-renewal activity to cell cycle quiescence. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
