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Ethambutol analogues as potential antimycobacterial agents.
Authors:H H?usler  R P Kawakami  E Mlaker  W B Severn  A E Stütz
Institution:1. Instituto Federal do Maranhão, CEP 65950-000 Barra do Corda, MA, Brazil;2. Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, CEP 66075-110 Belém, PA, Brazil;3. Departamento de Física, Universidade Federal do Maranhão, CCET, CEP 65080-805 São Luis, MA, Brazil;4. Universidade Federal do Maranhão, CCSST, CEP 65900-410 Imperatriz, MA, Brazil;1. Latvian Biomedical Research and Study Centre, Ratsupites Street 1, Riga, LV-1067, Latvia;2. Center of Tuberculosis and Lung Diseases, Riga East University Hospital, Stopinu p., Riga, LV-2118, Latvia;3. Rīga Stradiņš University, Dzirciema Street 16, Riga, LV-1007, Latvia
Abstract:A range of new ethambutol analogues was synthesised and their inhibitory potencies were probed with Mycobacterium smegmatis. Interestingly, apparently even minor deviation from the structure of the parent compound resulted in reduced antimycobacterial activity.
Keywords:
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