Serology and polymorphism ofH-2L- locus encoded antigens |
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Authors: | Chun-Ming Huang Huei-Jen Su Huang Jan Klein |
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Institution: | 1. Abteilung Immungenetik, Max-Planck-Institut für Biologie, D-7400, Tübingen, Federal Republic of Germany 2. Department of Microbiology, The University of Texas, Health Science Center, 75235, Dallas, Texas
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Abstract: | Thirty B10.W congenic lines were analysed serologically, both by direct cytotoxicity and by absorption, for the presence of H-2L antigens. Three new H-2L antigens, 73, 74, and 75, were discovered. The B10.W lines and the inbred strains can be classified into at least six H-2L phenogroups on the basis of their reactivity withH- 2dm2 anti-H- 2d serum: BALB/c, B10.BUA1, B10.GAA37, B10.BUA16. B10.KPB128, and the negative group. Twenty-oneD-end recom-binants were analysed for the possible separation ofH-2D andH-2L loci. The failure to find such a separation indicates that theH-2D andH-2L loci are tightly linked. Serological analysis also indicated that theH- 2dm1 has lost most of its H-2L antigens but retained at least one specificity which can be detected byH- 2dm2 anti-H- 2d serum. |
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