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Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia
Authors:Hongmei?Luo,Yu?Qin,Frederic?Reu,Sujuan?Ye,Yang?Dai,Jingcao?Huang,Fangfang?Wang,Dan?Zhang,Ling?Pan,Huanling?Zhu,Yu?Wu,Ting?Niu,Zhijian?Xiao,Yuhuan?Zheng  author-information"  >  author-information__contact u-icon-before"  >  mailto:yuhuan_zheng@.com"   title="  yuhuan_zheng@.com"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author,Ting?Liu  author-information"  >  author-information__contact u-icon-before"  >  mailto:liuting@scu.edu.cn"   title="  liuting@scu.edu.cn"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author
Affiliation:1.Department of Hematology, Hematology Research Laboratory, West China Hospital,Sichuan University,Chengdu,China;2.Department of Internal Medicine, Weiss Memorial Hospital,University of Illinois,Chicago,USA;3.Department of Haemotologic Oncology, Taussig Cancer Center,Cleveland Clinic,Cleveland,USA;4.Sinopec Southwest Company,Chengdu,China;5.State Key Laboratory of Biotherapy and Cancer Center,Sichuan University,Chengdu,China;6.Chinese Academy of Medical Sciences,Institute of Hematology and Blood Diseases Hospital,Tianjin,China
Abstract:

Background

Previous research suggested that single gene expression might be correlated with acute myeloid leukemia (AML) survival. Therefore, we conducted a systematical analysis for AML prognostic gene expressions.

Methods

We performed a microarray-based analysis for correlations between gene expression and adult AML overall survival (OS) using datasets GSE12417 and GSE8970. Positive findings were validated in an independent cohort of 50 newly diagnosed, non-acute promyelocytic leukemia (APL) AML patients by quantitative RT-PCR and survival analysis.

Results

Microarray-based analysis suggested that expression of eight genes was each associated with 1-year and 3-year AML OS in both GSE12417 and GSE8970 datasets (p?UBE2E1) expression was adversely correlated with AML survival (p?=?0.04). Multivariable analysis showed that UBE2E1 high patients had a significant shorter OS and shorter progression-free survival after adjusting other known prognostic factors (p?=?0.03). At last, we found that UBE2E1 expression was negatively correlated with patients’ response to induction chemotherapy (p?

Conclusions

In summary, we demonstrated that UBE2E1 expression was a novel prognostic factor in adult, non-APL AML patients.
Keywords:
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