Inhibition by somatostatin of the proliferation of T-lymphocytes and Molt-4 lymphoblasts |
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Authors: | D G Payan C A Hess E J Goetzl |
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Affiliation: | Howard Hughes Medical Institute and Division of Allergy & Immunology, University of California Medical Center, San Francisco, California 94143 USA |
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Abstract: | The proliferation of Molt-4 lymphoblasts and phytohemagglutinin-stimulated human T lymphocytes in vitro was inhibited significantly by 10(-12) to 10(-10) M to 10(-13) to 10(-9) M somatostatin, as assessed by the uptake of [3H]thymidine and [3H]leucine, respectively. The inhibitory effect of somatostatin was not attributable to cytotoxicity and was associated with a mean degradation of 52 and over 95% of immunoreactive somatostatin, respectively, after 3 and 24 hr of incubation at 37 degrees C. The specific suppression of Molt-4 lymphoblasts and T lymphocytes by somatostatin represents a distinct mechanism for the specific regulation of immunological responses by neuropeptides of the peripheral nervous system and gastrointestinal tract. |
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Keywords: | To whom reprint requests should be addressed: HSW-494 University of California Medical Center San Francisco Calif. 94143. |
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