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Miscellaneous terpenoid constituents of Abies nephrolepis and their moderate cytotoxic activities |
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| Authors: | Ou-Yang Dan-Wei Wu Liang Li Yong-Li Yang Pei-Ming Kong De-Yun Yang Xian-Wen Zhang Wei-Dong |
| Affiliation: | a Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China b Department of Chinese Traditional Medicine, Shanghai Institute of Pharmaceutical Industry, 1320 West Beijing Road, Shanghai 200040, China c Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China d School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China |
| Abstract: | Three monoterpenoids and two triterpenoids were isolated from Abiesnephrolepis together with 53 known terpenoids. The structures of the compounds were established by 1D and 2D NMR spectroscopy. The absolute configuration of 3-hydroxycamphane-2-carboxylic acid was established as (1S,2R,3S,4R) by Cu-Kα X-ray crystallography. All 58 isolates were tested for cytotoxic activity against four tumor cells viz. A549 (human lung adenocarcinoma), Colo205 (colon adenocarcinoma), QGY-7703 (human hepatoma) and THP-1 (human monocytic leukemia). α-Cadinol exhibited the best effects on A549, Colo205 and QGY-7703 with IC50 values of 8.6, 8.1 and 4.6 μg/mL, respectively. |
| Keywords: | Abies nephrolepis (Trautv.) Maxim Pinaceae Terpenoid Cu-Kα X-ray crystallography Cytotoxicity |
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