Acylphloroglucinol and xanthones from Hypericum ellipticum |
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| Authors: | Manning Kylie Petrunak Elyse Lebo Michelle González-Sarrías Antonio Seeram Navindra P Henry Geneive E |
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| Affiliation: | a Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, PA 17870, USA
b Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, 41 Lower College Road, University of Rhode Island, Kingston, RI 02881, USA |
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| Abstract: | An acylphloroglucinol, elliptophenone A, and two xanthones, elliptoxanthone A and elliptoxanthone B, were isolated from the aerial portions of Hypericum ellipticum together with three known xanthones, 1,3,7-trihydroxy-8-(3-methyl-2-butenyl)-9H-xanthen-9-one, 1,6-dihydroxy-4-methoxy-9H-xanthen-9-one, and 1,4,5-trihydroxy-9H-xanthen-9-one. Their structures were determined by spectroscopic analyses. The acylphloroglucinol and xanthones were evaluated for cytotoxicity using three human colon cancer cell lines cell lines (HT-29, HCT-116 and Caco-2) and a normal human colon cell line (CCD-18Co). |
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| Keywords: | Hypericum ellipticum Clusiaceae Acylphloroglucinol Xanthone Cytotoxicity |
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