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Cycloartane glycosides from Astragalus aureus |
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| Authors: | Gülcemal Derya Alankuş-Çalışkan Ozgen Perrone Angela Ozgökçe Fevzi Piacente Sonia Bedir Erdal |
| Affiliation: | a Department of Chemistry, Faculty of Science, Ege University, 35100 Bornova-?zmir, Turkey b Department of Pharmaceutical Sciences, Salerno University, 84084 Fisciano (Salerno), Italy c Department of Biology, Faculty of Science and Letters, Yüzüncü Y?l University, 65180 Van, Turkey d Department of Bioengineering, Faculty of Engineering, Ege University, 35100 Bornova-?zmir, Turkey |
| Abstract: | Eight cycloartane-type triterpene glycosides (1-8) were isolated from Astragalus aureus Willd along with ten known cycloartane-type glycosides (9-18). Their structures were established by the extensive use of 1D and 2D-NMR experiments along with ESIMS and HRMS analyses. Compounds 1-5 are cyclocanthogenin glycosides, whereas compounds 6-8 are based on cyclocephalogenin as aglycon, more unusual in the plant kingdom, so far reported only from Astragalus spp. Moreover, for the first time monoglycosides of cyclocanthogenin (5) and cyclocephalogenin (7, 8) are reported. All of the compounds tested for their cytotoxic activities against a number of cancer cell lines. Among the compounds, only 8 exhibited activity versus human breast cancer (MCF7) at 45 μM concentration. |
| Keywords: | Astragalus aureus Saponin Cycloartane Cyclocephalogenin Cyclocanthogenin Cytotoxic activity |
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