Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach |
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Authors: | Juan J. Araya |
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Affiliation: | Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA |
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Abstract: | Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts. |
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Keywords: | Ginger Zingerines Alkaloids Phase-trafficking Natural products Fractionation |
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