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Molecular analyses of the Chinese herb Leigongteng (Tripterygium wilfordii Hook.f.) |
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| Authors: | Law Sue Ka-Yee Simmons Mark P Techen Natascha Khan Ikhlas A He Ming-Fang Shaw Pang-Chui But Paul Pui-Hay |
| Institution: | a Food and Drug Authentication Laboratory, Department of Biology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China b Department of Biochemistry and Centre for Protein Science and Crystallography, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China c Department of Biology, Colorado State University, Fort Collins, CO 80523, USA d National Center for Natural Products Research and Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, School of Pharmacy, University of Mississippi, P.O. Box 1848, University, MS 38677, USA e Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, PR China |
| Abstract: | Tripterygium wilfordii Hook.f., known as Leigongteng (Thunder God Vine) in traditional Chinese medicine, has attracted much attention for its applications in relieving autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus, and for treating cancer. Molecular analyses of the ITS and 5S rDNA sequences indicate that T. hypoglaucum and T. doianum are not distinct from T. wilfordii, while T. regelii should be recognized as a separate species. The results also demonstrate potential value of rDNA sequence data in forensic detection of adulterants derived from Celastrusangulatus in commercial samples of Leigongteng. |
| Keywords: | Tripterygium Leigongteng DNA sequences Phylogeny Adulterant |
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