Caucasicosides E-M, furostanol glycosides from Helleborus caucasicus |
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Authors: | Muzashvili Tamar Perrone Angela Napolitano Assunta Kemertelidze Ether Pizza Cosimo Piacente Sonia |
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Institution: | a Institute of Pharmacochemistry, P. Sarajishvili Street 36, 0159 Tbilisi, Georgia b Dipartimento di Scienze Farmaceutiche e Biomediche, Università degli Studi di Salerno, Via Ponte Don Melillo, I-84084 Fisciano, Italy |
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Abstract: | Nine furostanol glycosides, namely caucasicosides E-M, were isolated from the MeOH extract of the leaves of Helleborus caucasicus, along with 11 known compounds including nine furostanol glycosides, a bufadienolide and an ecdysteroid. Their structures were established by the extensive use of 1D and 2D NMR experiments along with ESIMSn analyses. The steroidal composition of leaves of H. caucasicus shows as particular feature the occurrence of steroidal compounds belonging to the 5β series, unusual for Helleborus species, and in particular, caucasicosides F-H are based on a 5β-polyhydroxylated steroidal aglycon never reported before. |
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Keywords: | Helleborus caucasicus Ranunculaceae Furostanol glycosides 5β-Polyhydroxylated steroids |
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