Furanocoumarins from Dorsteniafoetida |
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| Authors: | Ramona Heinke Andrea Porzel Nasser A. Awadh Ali |
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| Affiliation: | a Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle/Saale, Germany
b Pharmacognosy Department, Faculty of Pharmacy, Sana’a University, P.O. Box 13150, Sana’a, Yemen |
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| Abstract: | The linear furanocoumarins 5-(2,3-epoxy-3-methyl-butoxy)-chalepensin, 5-methoxy-3-(3-methyl-2,3-dihydroxybutyl)-psoralen-diacetate (7), 5-methoxy-3-[3-(β-d-glucopyranosyloxy)-2-acetyloxy-3-methyl-butyl]-psoralen and 5-(3-methyl-2,3-dihydroxybutyloxy)-3-[3-(β-d-glucopyranosyloxy)-2-hydroxy-3-methyl-butyl]-psoralen, and the coumarin derivative 7-hydroxy-5-methoxy-6-carboxymethyl-3-[3-(β-d-glucopyranosyloxy)-2-hydroxy-3-methyl-butyl]-coumarin were isolated from the leaves of Dorstenia foetida (Moraceae) along with the known compounds psoralen, bergapten, isopimpinellin, phellopterin, 5-methoxychalepensin and turbinatocoumarin. Further furanocoumarins were characterized by ESI-MS/MS investigations. The nonpolar extracts of D. foetida exhibit antifungal, antibacterial and cytotoxic activity, however, no anthelminthic activity. |
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| Keywords: | Dorstenia foetida Moraceae Phytochemistry Furanocoumarins 7-Hydroxy-5-methoxy-6-carboxymethyl-3-[3-(β- smallcaps" >d-glucopyranosyloxy)-2-hydroxy-3-methyl-butyl]-coumarin |
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