Converging evidence for a simplified biophysical model of synaptic plasticity |
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Authors: | Shouval Harel Z Castellani Gastone C Blais Brian S Yeung Luk C Cooper Leon N |
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Institution: | (1) Institute for Brain and Neural Systems and Department of Physics Brown University, 02912,;(2) Physics Department and Dimorfipa, Bologna University, Bologna 40121, Italy, IT;(3) Bryant College, Smithfield, RI, |
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Abstract: | Different mechanisms that could form the molecular basis for bi-directional synaptic plasticity have been identified experimentally
and corresponding biophysical models can be constructed. However, such models are complex and therefore it is hard to deduce
their consequences to compare them to existing abstract models of synaptic plasticity. In this paper we examine two such models:
a phenomenological one inspired by the phenomena of AMPA receptor insertion, and a more complex biophysical model based on
the phenomena of AMPA receptor phosphorylation. We show that under certain approximations both these models can be mapped
on to an equivalent, calcium-dependent, differential equation. Intracellular calcium concentration varies locally in each
postsynaptic compartment, thus the plasticity rule we extract is a single-synapse rule. We convert this single synapse plasticity
equation to a multi-synapse rule by incorporating a model of the NMDA receptor. Finally we suggest a mathematical embodiment
of metaplasticity, which is consistent with observations on NMDA receptor properties and dependence on cellular activity.
These results, in combination with some of our previous results, produce converging evidence for the calcium control hypothesis
including a dependence of synaptic plasticity on the level of intercellular calcium as well as on the temporal pattern of
calcium transients.
Received: 24 April 2002 / Accepted: 15 May 2002
Acknowledgements. LCY was supported by a Burroughs Wellcome fellowship, GCC by Murst 60%.
Correspondence to: H. Z. Shouval (e-mail: Harel_Shouval@brown.edu) |
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