The inhibition of NF-kB activation decreases the resistance of acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates |
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| Authors: | R. S. Fadeev M. E. Solovieva D. A. Slyadovskiy S. G. Zakharov I. S. Fadeeva A. S. Senotov A. K. Golenkov V. S. Akatov |
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| Affiliation: | 1.Institute of Theoretical and Experimental Biophysics,Russian Academy of Sciences,Pushchino, Moscow oblast,Russia;2.Pushchino State Natural Science Institute,Pushchino, Moscow oblast,Russia;3.Vladimirsky Moscow Regional Research Clinical Institute,Moscow,Russia |
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| Abstract: | The suppression of resistance in acute myeloid leukemia cells to TRAIL-induced apoptosis in multicellular aggregates was studied using small molecular inhibitors of the activation of the transcription factor NF-kB, viz., NF-kB Activation Inhibitor IV and JSH-23 at nontoxic concentrations. NF-kB Activation Inhibitor IV and JSH-23 decreases the resistance of acute myeloid leukemia cells in multicellular aggregates to the cytotoxic action of the izTRAIL recombinant protein. It has been shown that the use of these inhibitors decreased the phosphorylation of RelA (p65) as a major marker of the activation of the NF-kB transcription factor. The potential causes of the increased resistance of acute myeloid leukemia cells to TRAIL-induced apoptosis in multicelluar aggregates are discussed. |
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